Arf Family GTPase
ADP-ribosylation Factor (ARF) Family GTPase
ADP-ribosylation factor (Arf) GTPases are a subfamily of the Ras superfamily of small GTPases. In mammals, there are approximately 30 members of the ARF GTPases family, divided into "true ARFs" (6 types) and "ARF-like" (ARL) proteins (21 types), as well as other related proteins such as SARs. ARF GTPases play a crucial role in regulating membrane trafficking and organelle structure. They are activated and deactivated through GTP binding and hydrolysis, mediated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). ARF GTPases regulate a variety of key cellular processes such as vesicle formation, protein sorting, lipid remodeling, and the dynamics of the cytoskeleton, thereby affecting secretion, endocytosis, and cell adhesion. Their activity involves interactions with a variety of effectors, including coat proteins, lipid-modifying enzymes, and scaffold proteins.
The aberrant expression or dysfunction of ARF GTPases is associated with various disease states, including neurodegenerative diseases, tumors, and immune system disorders. Specifically, the role of ARF GTPases in membrane remodeling and cell signaling makes them potential targets for research into these diseases[1].
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Arf Family GTPase Related Products (15)
Related Products (15)
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Bragsin1
0 ImagesBragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity.
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ART5537
0 ImagesCat. No.: HY-180573Purity: 99.84%ART5537 is a selective EXO1 inhibitor with a IC50 of 3.4 nM and a Kd of 6.8 nM. ART5537 exerts cellular homologous recombination (HR) inhibition with EC50 of 7.2 nM in HAP1 parental cells. ART5537 shows >200-fold selectivity over a panel of the wider nuclease superfamily. ART5537 exerts biological effects that are exclusively driven by EXO1 inhibition. ART5537 demonstrates sensitization to ionizing radiation and synergy with Olaparib (HY-10162). ART5537 can be used for research in breast cancer and colorectal adenocarcinoma.
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CHNQD-01255
0 ImagesCat. No.: HY-151461CAS No.: 2756173-91-6CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy.
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Brefeldin A 4-O-nicotinate
0 ImagesCat. No.: HY-173280CAS No.: 3035018-34-6Synonyms: CHNQD-01228Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC50 value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer.
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Arf1-GEFs-IN-1
0 ImagesCat. No.: HY-175290CAS No.: 3091068-95-7Arf1-GEFs-IN-1 is a potent and orally active ADP-ribosylation factor 1- guanine nucleotide exchange factors (Arf1-GEFs) inhibitor with an IC50 value of 40.85 μM against CT26 cells. Arf1-GEFs-IN-1 primarily mediates tumor regression by triggering anti-tumor immune responses, rather than through direct cytotoxicity. Arf1-GEFs-IN-1 effectively promotes CCL5 expression, demonstrates excellent in vivo efficacy. Arf1-GEFs-IN-1 can be used for the study of colon cancer.
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ARF6 (2-13)
0 ImagesCat. No.: HY-P10179CAS No.: 1026775-53-0ARF6 (2-13) is a peptide with a sequence of GKVLSKIFGNKE. ARF6 (2-13) is an inhibitor of ARF6. ARF6 (2-13) can be used in the research of endotoxemia.
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TNP-β-L-GTP tetrasodium
0 ImagesCat. No.: HY-173535Synonyms: TNP-β-L-Guanosine 5'-triphosphate tetrasodiumTNP-β-L-GTP (TNP-β-L-Guanosine 5'-triphosphate) tetrasodium is a fluorescent GTP mimetic that can be used to study the binding kinetics and affinity of GTP-binding proteins (such as G proteins and GTPases). TNP-β-L-GTP tetrasodium carries a TNP fluorophore, which changes fluorescence intensity upon protein binding, allowing for quantitative analysis.
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CHNQD-01269
0 ImagesCat. No.: HY-177269CAS No.: 2648988-92-3CHNQD-01269, a brefeldin A-cinnamate derivative, is an Arf1 inhibitor. CHNQD-01269 exhibits potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC50 values of 0.29 and 0.84 μM, respectively. CHNQD-01269 is indicated for hepatocellular carcinoma (HCC) research.
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N-Deacetylcolchicine tartrate
0 ImagesCat. No.: HY-121434ACAS No.: 49720-72-1N-Deacetylcolchicine tartrate is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine tartrate is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine tartrate can activate the GTPase activity of microtubules and can be used for the research of cancer.
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N-Deacetylcolchicine
0 ImagesN-Deacetylcolchicine is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine can activate the GTPase activity of microtubules and can be used for the research of cancer.
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